Rabbit anti-Human IL22RA1 Polyclonal Antibody

Uniprot Id

Q8N6P7

Target Species

Human

Target Name

IL22RA1

Target Full Name

Interleukin-22 receptor subunit alpha-1

Target Function

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Type II cytokine receptor family

Target Tissue Specificity

Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial

Target Research Area

Immunology

Target Synonyms

CRF2 9; CRF2-9; Cytokine receptor class-II member 9; cytokine receptor classII member 9; Cytokine receptor family 2 member 9; I22R1_HUMAN; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; IL22 Receptor Alpha; IL22R; IL22R1; Il22ra1; ILTIF R1 chain; Interleukin 22 Receptor alpha 1; Interleukin 22 Receptor; Interleukin-22 receptor subunit alpha-1; ZcytoR11

Target Background

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.