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The antibody against AKAP10 was raised in rabbit using the Recombinant Human A-kinase anchor protein 10, mitochondrial protein (413-662AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against AKAP10 was raised in rabbit using the Recombinant Human A-kinase anchor protein 10, mitochondrial protein (413-662AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human breast cancer using AKAP10 Antibody at dilution of 1:1002
| Cat.No | ADC-40460A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AKAP10 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | mitochondrial protein (413-662AA), Recombinant Human A-kinase anchor protein 10 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | and peptides are available upon request., Complete sequences for the immunogen, target protein | Uniprot ID | O43572 |
Uniprot Id
O43572
Target Species
Human
Target Name
AKAP10
Target Full Name
A-kinase anchor protein 10, mitochondrial
Target Function
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
Target Involvement
Sudden cardiac death (SCD)
Target Subcellular Location
Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
Target Synonyms
AKAP10A-kinase anchor protein 10; mitochondrial; AKAP-10; Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10
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